Pharmacology Core Mission
The URI Pharmacology Core provides advanced, quantitative pharmacokinetic support to COBRE researchers at URI and Brown, as well as the broader research community. Established to foster collaboration across pharmacological sciences, the Core aims to build an important role in supporting the progression of drug discovery from early research stages.
Our Assets
PharmCore URI resources extensive experience of faculty and staff in biological sample preparation, quantitative mass spectrometric drug concentration measurement, and pharmacokinetic data modeling.
Expertise includes optimizing the design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies.
Consultations Offered
- Research planning
- Experimental design
- Study conduct
- Data analysis
- Results interpretation
- Manuscript preparation
Services Offered
- In Vitro Pharmacokinetic modeling:
- Permeability Assays
- Stability Assay
- In Vivo (rodent) single-dose pharmacokinetic analysis
- Plasma protein binding (PPB) assays of drugs and small molecules:
- RED (rapid equilibrium dialysis)
- C18 binding
Equipment Available
- Waters Xevo TQ-XS
- AB SCIEX TripleTOF 5600+
- Agilent 6470B Triple Quadrouple LC-MS
- Thermo Scientific Orbitrap Exploris 240 LC-MS
- SCIEX ExionLC AC UHPLC coupled to a SCIEX X500R QTOF-MS/MS
- Biological safety level II laminar flow hoods
